Figure 8.

Interaction between ischemia and hyperglycemia-induced signaling in NF-κB activation and perfusion recovery in PAD. Both ischemia and hyperglycemia induce signaling to activate NF-κB that is required for perfusion recovery. However, chronic hyperglycemic conditions attenuate the ischemia-induced activation of the canonical NF-κB pathway and contribute to poor perfusion recovery, through the effects of increased phosphorylation of PKCβ (PKCβ-pSer661). Inhibition of PKCβ activity by the specific inhibitor ruboxistaurin (Rbx) restores the canonical NF-κB pathway and improves perfusion recovery in diabetic mice after PAD. (A color version of this figure is available in the online journal.)

PKCβ: protein kinase C beta; NF-κB: nuclear factor-kappa B.