Table 5.
Comparison results of laboratory of different severity grade patients with COVID-19.
| Laboratory index | Mild (n = 99) | Severe (n = 4) | Critical (n = 11) | P | |
|---|---|---|---|---|---|
| Blood routine | Leucocytes (× 109 per L; 3.5–9.5) | 5.01 (1.83) | 6.62 (2.79) | 5.90 (3.66) | <0.001 |
| Neutrophils granulocyte (%; 50–70) | 58.06 (11.56)ab | 71.73 (7.02) | 75.28 (13.19) | <0.001 | |
| Lymphocytes (× 109 per L; 1.1–3.2) | 1.60 (1.02)a | 1.25 (0.35) | 0.87 (0.44) | >0.05 | |
| Platelets (× 109 per L; 125.0–350.0) | 185.38 (80.21)b | 313.50 (146.28) | 168.45 (106.32) | 0.047 | |
| Hemoglobin (g/L; 130.0–175.0) | 134.77 (16.417) | 120.75 (9.98) | 135.82 (11.55) | >0.05 | |
| Cluster of differentiation 4 (per μl; 500–1,600) | 475.49 (235.02)ab | 251.00 (185.06) | 237.40 (160.80) | <0.001 | |
| Blood biochemistry | Albumin (g/L; 40.0–55.0) | 42.07 (4.01)a | 38.08 (6.12) | 37.91 (3.30) | 0.003 |
| Alanine aminotransferase (U/L; 9.0–50.0) | 28.06 (28.02)a | 27.25 (19.26) | 48.36 (39.30) | 0.045 | |
| Aspartate aminotransferase (U/L; 15.0–40.0) | 27.70 (19.14)a | 28.50 (15.07) | 44.91 (35.41) | 0.003 | |
| Total bilirubin (μmol/L; 0.0–21.0) | 15.39 (10.27) | 15.05 (8.50) | 18.86 (9.17) | >0.05 | |
| Blood urea nitrogen (mmol/L; 3.6–9.5) | 3.84 (1.23) | 4.68 (1.63) | 4.08 (1.30) | >0.05 | |
| Serum creatinine (μmol/L; 57.0–111.0) | 69.84 (20.61) | 69.63 (9.16) | 69.15 (19.28) | >0.05 | |
| Creatine kinase (U/L; 50.0–310.0) | 88.80 (64.93) | 201.00 (202.43) | 278.73 (476.09) | >0.05 | |
| Infection-related biomarkers | Procalcitonin (ng/mL; 0.0–5.0) | 0.05 (0.06)ab | 0.02 (0.00)c | 0.16 (0.32) | 0.014 |
| Erythrocyte sedimentation rate (mm/h; 0.0–15.0) | 36.72 (26.11) | 59.33 (24.54) | 43.30 (17.75) | >0.05 | |
| C-reactive protein (mg/L; 0.0–5.0) | 16.75 (26.98)a | 7.56 (3.62)c | 51.86 (34.94) | <0.001 | |
| Myocardial injury markers | Creatine kinase (U/L; normal range 50.0–310.0) | 88.80 (64.93) | 201.00 (202.43) | 278.73 (476.09) | >0.05 |
| Creatine kinase isoenzymes, CK-MB (U/L; normal range 0–18) | 11.12 (10.18) | 10.20 (3.13) | 12.75 (8.69) | >0.05 | |
| pro-Brain Natriuretic Peptide (pg/mL; normal range <100) | 1705.28 (2326.45) | 170.40 (0.00) | 270.06 (225.67) | >0.05 | |
| Troponin (μg/L; normal range <0.2) | 14.05 (6.58) | 8.25 (2.71) | 6.35 (2.10) | >0.05 | |
| Blood gas analysis | PH (normal range 7.35–7.45) | 7.42 (0.07) | 7.44 (0.07) | 7.47 (0.06) | >0.05 |
| PO2 (normal range 10.64–13.3 kPa or 80–100 mmHg) | 90.90 (23.81) | 83.75 (25.41) | 71.73 (19.66) | >0.05 | |
| PCO2 (normal range 4.65-5.98 kPa or 35–45 mmHg) | 43.70 (4.81) | 41.50 (7.05) | 41.36 (19.19) | >0.05 | |
| Fraction of inspiration O2, FiO2 | 24.00 (4.92)ab | 33.50 (9.29)c | 49.91 (14.38) | <0.001 | |
| PO2/FiO2 | 376.90 (46.89)ab | 252.00 (53.39)c | 162.45 (45.03) | <0.001 |
a
Difference between the mild and severe groups had statistical significance (p < 0.05).
b
Difference between the mild and critical groups had statistical significance (p < 0.05).
c
Difference between the severe and critical groups had statistical significance (p < 0.05).