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. 2020 May 29;11:467. doi: 10.3389/fneur.2020.00467

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Copyright © 2020 Oliveira Young, Etchbehere, Souza, Brunetto, Santos, Lima, Ortiz-De la Rosa, Alvim, Yasuda, Ramos, Cendes and Amorim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Patient #11 had tuberous sclerosis and refractory epilepsy. The axial images of the (A) ictal SPECT and the (B) interictal SPECT visual analysis showed a possible epileptogenic zone in the right frontal lobe. (C) The axial images in the SISCOM performed with SPM showed two foci of hyperperfusion in the right frontal and right occipital lobes (arrows). MRI showed the largest tubers in these two regions, and compatible with the main epileptogenic zone identified by EEGs and long-term video-EEG. This patient was submitted to surgery with resection of both tubers, resulting in cessation of seizure.