Table 1.

Patients characteristics with and without antibiotics before ICU stay

	Without antibiotics (n=29)	With antibiotics (n=19)	p-value
Age, median (IQR)	66 [60; 71]	67 [60; 72]	0.74
Sex, female	5 (17.2)	6 (31.6)	0.25
≥1 comorbidity	22 (75.9)	16 (84.2)	0.49
Cardiovascular disease	11 (37.9)	3 (15.8)	0.12
Diabetes mellitus	7 (24.1)	6 (31.6)	0.57
Hypertension	16 (55.2)	8 (42.1)	0.38
Lymphopenia at admission, median (IQR)	0.7 [0.6; 0.9]	0.7 [0.4; 0.9]	0.33
CRP at admission, median (IQR)	128 [57; 206]	83 [47; 132]	0.29
Creatinin at admission, median (IQR)	95 [84; 118]	98 [81; 128]	0.92
Lymphopenia duration, median (IQR)	23 [16; 31]	25 [23; 35]	0.11
SAPS at ICU admission, median (IQR)	45 [40; 65]	47 [37; 55]	0.79
Corticosteroids during ICU stay	15 (51.7)	10 (52.6)	0.95
Antivirals*	14 (48.3)	13 (68.4)	0.17
Tocilizumab	3 (10.3)	2 (10.5)	0.99
Healthcare-associated infections during ICU stay
Infection number per patient, median (IQR)	1 [1; 2]	1 [1; 2]	0.98
VAP	19 (65.5)	14 (73.7)	0.55
UTI	8 (27.6)	2 (10.5)	0.28
CRBSI	7 (24.1)	5 (26.3)	0.86
Colitis	0 (0)	1 (5.3)	0.39
Candidemia	2 (6.9)	3 (15.8)	0.37
Mortality	7 (24.1)	5 (26.3)	0.86

Legends. *Antivirals commonly administered at our institution were: hydroxychloroquin, lopinavir/ritonavir and remdesivir. IQR: interquartile range. CRP: C-reactive protein. SAPS: Simplified Acute Physiology Score. ICU: Intensive care unit. VAP: Ventilator-associated pneumonia. UTI: Urinary tract infection. CRBSI: Catheter-related bloodstream infection.