FIGURE 6.

Muscle morphometric analysis. Absolute muscle weights of both 3.5-months (left) and 6-month (right) old male mice (A,B). Ttn^Δ219–225 mice display an early weight and skeletal system growth deficit [side panels (A,B), respectively], compared to wildtype litter mates, which normalizes at 6 months of age (N = 11–14). Muscle weights are generally unaffected early on, except in the soleus (p < 0.01), with progressive increases in muscle mass as the mice age. t-test; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.