Table 2.

Pretreatment Characteristics: Primary Cancer

Variable		No. of Patients	%
Total		1048	100.0
New diagnosis of cancer
• Yes		302	28.8
• No		681	65.0
• CUP		58	5.5
• NA		7	0.7
Location of primary
• Lung		383	36.5
• Breast		193	18.4
• Melanoma		126	12.0
• Upper GI tract		34	3.2
• Lower GI tract		58	5.5
• Kidney		49	4.7
• Prostate		13	1.2
• Genitourinary		46	4.4
• Multiple		23	2.2
• Other		43	4.1
• CUP/NA		80	7.6
Extracranial disease
• None		54	5.2
• Controlled	➢Primary site disease only	194	18.5
	➢Metastatic disease	157	15.0
• Uncontrolled	➢Primary site disease only	63	6.0
	➢Metastatic disease	168	16.0
• NA		412	39.3
Molecular markers
• Positive		216	20.6
• Negative		108	10.3
• NA		747	71.3
Time intervala, y
• ≤ 2		353	33.7
• > 2		239	22.8
• NA		456	43.5
Extracranial metastasis
• Yes		467	44.6
• No		536	51.1
• NA		45	4.3

Abbreviations: CUP, cancer of unknown primary; GI, gastrointestinal; NA, not available (unknown or not recorded).

^aTime between diagnosis of primary tumor and cerebral metastasis, where applicable.