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. Author manuscript; available in PMC: 2020 Jun 5.
Published in final edited form as: Nat Med. 2019 Jul 29;25(8):1280–1289. doi: 10.1038/s41591-019-0512-5

Figure 4. Identification of modulated SMCs in diseased human coronary arteries.

Figure 4.

(a) t-SNE visualization of cell types isolated from the right coronary artery of four human patients, with assigned cell cluster identities indicated. (b-c) t-SNE visualization overlaid with expression of CNN1 (b) and FN1 (c). Expression levels are indicated by scales in the lower right of each panel. Data from n=4 patients. (d) In a joint mouse/human clustering analysis, a distinct population of human cells (brown) clustered together with lineage-traced fibromyocytes in the mouse. (e) t-SNE visualization overlaid with expression of TNFRSF11B. (f) RNAscope in-situ hybridization of TNFRSF11B in a human coronary artery. Image is representative of 4 experiments, and scale bar represents 50μm.