Figure 3. SRF and TCF21 show opposing binding behavior in many colocalized regions of the genome.

SRF and TCF21 joint binding regions were evaluated for degree of occupancy by each factor. DNA binding was assessed by comparing peak reads normalized to background reads at each locus and this variable graphed. Most of the colocalized binding regions were biased for either SRF or TCF21 binding, with a greater than 2-fold number of normalized reads for one or the other factor.