Why carry out this study?

Dysfunctional coagulation is one of the important risk factors accountable for the high risk of severe disease and death in patients with coronavirus disease 2019 (COVID-19) infection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) involves potentially deleterious processes in hemostasis/coagulation and the inflammation system.

This article aims to discuss the possible mechanisms underlying dysfunctional coagulation during SARS-CoV-2 infection.

What was learned from the study?

Abnormal activation of the renin-angiotensin system (RAS) and a systemic endotheliitis caused by dysfunction of angiotensin-converting enzyme 2 (ACE2), the innate immune response and inflammation activation participate in dysfunctional coagulation.

To propose an appropriate anticoagulation therapeutic regimen and reduce the fatality rate during the ongoing COVID-19 pandemic.