Table 1.
Relative reinforcing effects of cocaine, methamphetamine, MDPV, and α-PVP in rhesus monkeys.
| ED50 mg/kg/inf (95% CI) | Emax | Max Duration min (SEM) | ||
|---|---|---|---|---|
| Infusions (SEM) | Final Ratio (SEM) | |||
| cocainea | 0.012 (0.01-0.014) | 20.1 (1.0)# | 1936 (270) | 436 (28) |
| cocaineb | 0.011 (0.007-0.017) | 20.7 (0.6)# | 2133 (229) | 483 (40) |
| methamphetamine | 0.0045 (0.0033-0.0062) | 15.9 (1.1) | 913 (168) | 447 (39) |
| MDPV | 0.0025 (0.0016-0.0040) | 22.8 (1.0)# | 3133 (668)# | 841 (131)*,# |
| α-PVP | 0.0029 (0.0016-0.0052) | 24.3 (1.1)*,# | 4260 (917)*,# | 755# (121) |
a
initial evaluation of cocaine;
b
terminal evaluation of cocaine
*
significant difference from cocaine as determined by one-way ANOVA with post-hoc Tukey’s tests;
#
significant difference from methamphetamine as determined by one-way ANOVA with post-hoc Tukey’s tests