Table 2. Lung function, COPD-related scores and multicomponent indices, and hematological and biochemical parameters in COPD patients subdivided according to low and high UA and UCR levels.
| parameter | low UA | high UA | P | low UCR | high UCR | P |
|---|---|---|---|---|---|---|
| n = 83 | n = 26 | n = 72 | n = 37 | |||
| FEV1 (L) | 1.05 | 1.34 | 0.361 | 1.30 | 0.80 | 0.001 |
| (0.68–1.60) | (0.80–1.60) | (0.85–1.66) | (0.53–1.36) | |||
| FEV1 (% pred.) | 40 | 49 | 0.278 | 47 | 31 | 0.006 |
| (27–58) | (31–62) | (30–64) | (19–52) | |||
| FEV1/FVC | 0.50 | 0.53 | 0.527 | 0.54 | 0.47 | 0.023 |
| (0.40–0.59) | (0.46–0.59) | (0.42–0.61) | (0.40–0.54) | |||
| mMRC score | 2.00 | 1.00 | 0.780 | 1.50 | 2.00 | 0.231 |
| (1.00–2.75) | (1.00–3.00) | (1.00–2.00) | (1.00–3.00) | |||
| CAT score | 17.00 | 20.50 | 0.224 | 15.50 | 22.00 | 0.001 |
| (12.00–22.75) | (13.00–26.00) | (11.00–20.50) | (16.75–28.00) | |||
| SGRQ-C score | 44.60 | 48.65 | 0.536 | 41.10 | 49.40 | 0.034 |
| (27.13–63.05) | (32.00–64.60) | (26.20–60.50) | (35.95–75.63) | |||
| previous exacerbations | 1 | 1 | 0.938 | 1 | 1 | 0.033 |
| (0–2) | (0–2) | (0–1) | (0–2) | |||
| BODCAT | 5.00 | 4.00 | 0.867 | 4.00 | 6.00 | 0.006 |
| (3.00–7.00) | (3.00–7.00) | (2.00–7.00) | (4.00–8.00) | |||
| BODEx | 4.00 | 2.50 | 0.598 | 3.00 | 4.00 | 0.049 |
| (2.00–5.75) | (1.00–6.00) | (1.00–5.00) | (2.00–6.00) | |||
| WBC (x109/L) | 7.40 | 7.67 | 0.359 | 7.57 | 7.61 | 0.675 |
| (6.35–8.86) | (6.75–9.17) | (6.47–8.86) | (6.61–9.26) | |||
| CRP (mg/L) | 2.19 | 4.20 | 0.193 | 2.15 | 3.32 | 0.150 |
| (1.15–4.55) | (1.10–5.90) | (1.12–4.38) | (1.20–6.52) | |||
| Fbg (g/L) | 3.7 | 3.9 | 0.235 | 3.8 | 3.9 | 0.411 |
| (3.4–4.4) | (3.6–4.5) | (3.4–4.4) | (3.5–4.7) | |||
| IL-1β (pg/mL) | 3.390 | 8.242 | 0.267 | 3.683 | 10.554 | 0.033 |
| (0.364–19.704) | (1.068–25.455) | (0.426–11.515) | (1.494–25.936) |
All of the parameters were assessed by Mann-Whitney Rank Sum test and are presented as median with interquartile range. Data were considered significant if P<0.05. Previous exacerbations were defined as the number of exacerbations in the previous year.
UA, uric acid; UCR, uric acid to creatinine ratio; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; mMRC, modified Medical Research Council; CAT, COPD Assessment Test; SGRQ-C, St. George’s respiratory questionnaire for COPD patients; BODCAT–body mass index (BMI), airflow obstruction, dyspnea, score from COPD Assessment Test (CAT); BODEx–body mass index (BMI), airflow obstruction, dyspnea, previous exacerbations; WBC, white blood cells; CRP, C-reactive protein; Fbg, fibrinogen; IL-1β, interleukin 1 beta.