Table 1. Summary of the results (MNI coordinates and cluster size) across the four analyses (experiments 1 to 4) and two imaging methods (DBM or resting-state fMRI).
| Analysis Type | DBM | Resting-State fMRI | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Contrast | DisRev > All Controls | DisRev > Dis Controls | Lesion < Controls* | DisRev > All Controls | DisRev > Dis Controls | Lesion < Controls | ||||||
| Area | MNI (x, y, z) |
Cluster (number of voxels) | MNI (x, y, z) |
Cluster (number of voxels) |
MNI (x, y, z) |
Cluster (number of voxels) |
MNI (x, y, z) |
Cluster (number of voxels) |
MNI (x, y, z) |
Cluster (number of voxels) |
MNI (x, y, z) |
Cluster (number of voxels) |
| lOFC/12o | 15.5, 14, 4 | 27 | 15.5, 14.5, 4 | 18 | 14.5, 13.5, 1 | 6,673 | −12, 14, 3 | 17 | −12, 14, 3.5 | 31 | 12.5, 10.5, −5 | 36 |
| lPFC | 16, 11, 8.5 | 110 | 17, 10, 8.5 | 70 | 7.5, 21, 7 | 6,673 | - | - | - | - | - | - |
|
ACC/ MCC |
2.5, 9, 9.5 | 86 | 3.5, 10.5, 10 | 75 | 4, 18.5, 10.5 | 6,673 | - | - | - | - | 2, 20.5, 7.5 0, 20, 7.5 |
184 298 |
| plOFC/AI | 14.5, 3, −7.5 | 256 | 14, 3.5, −6.5 | 309 | 12.5, 4, −1.5 | 6,673 | - | - | - | - | - | - |
*All frontal regions fall within a large cluster of lesion effects.
Abbreviations: 12o, orbital part of area 12; ACC/MCC, anterior cingulate cortex/midcingulate cortex; AI, anterior insula; DBM, deformation-based morphometry; Dis Control, discrimination control; DisRev, discrimination reversal; fMRI, functional magnetic resonance imaging; lOFC, lateral OFC; lPFC, lateral prefrontal cortex; MNI, Montreal neurological institute; OFC, orbitofrontal cortex; plOFC, posterior lOFC; plOFC/AI, plOFC extending into AI.