Fig 1. Glut10G128E mice are predisposed to HFD-induced glucose intolerance and insulin resistance.
Glut10G128E mice and WT mice were fed with a CD or HFD from 5 to 20 weeks of age. Data were collected from the mice at indicated of age or at the conclusion of feeding (20 weeks of age). (A) Representative photograph of mice at 20 weeks of age. Each square on the green mat is 1 cm × 1 cm. (B) Body weights are shown for indicated ages. n = 20−40 mice per group. (C) Fasting glucose, (D) HbA1c levels, and (E) fasting insulin levels were measured at 20 weeks of age. (F) Glucose tolerance test (GTT) was performed in 16-week-old mice and (G) insulin tolerance test (ITT) was performed in 18-week-old animals. Right panels in F and G respectively show the areas under the GTT and ITT curves (AUC). n = 6 mice per group. (H) GTT was performed in WT and Glut10G128E mice on a CD at 24 months of age. n = 6 mice per group. The data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.