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. 2020 May 26;14:2079–2090. doi: 10.2147/DDDT.S244059

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© 2020 Xu et al.

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IL-1β or resveratrol treatment promoted activation of the PI3K/Akt signaling but led to inactivation of FoxO1 in SW1353 cells. (A), (C) Serum-starved (0.5% FBS) SW1353 cells were treated with 10 ng/mL IL-1β or resveratrol (50 μM) for 10, 15, 30, 60 and 120 min. p-PI3K, p-Akt, and p-FoxO1 expression were determined by Western blot analysis. (B), (D) The levels of p-PI3K, p-Akt, p-FoxO1 were normalized with their respective total PI3K, Akt, FoxO1 levels. The results for Western blot were expressed as folds of CON. Data were expressed as the mean ± SD of three independent experiments. *P <0.05, **P <0.01 versus the CON group.