Table 6.
Association between ACEI/ARB with a composite endpoint of death and heart failure
| Event | Death + heart failure (whole cohort) |
Death + heart failure (admitted to hospital) |
||||
|---|---|---|---|---|---|---|
| Univariate analysis | ||||||
| OR | 95%CI | P | OR | 95%CI | P | |
| ACEI/ARB | 1.85 | 1.08-3.15 | .025 | 1.35 | 0.56-3.26 | .499 |
| ACEI/ARB ≥ 1 y | 2.21 | 1.27-3.84 | .005 | 1.27 | 0.66-2.47 | .477 |
| ACEI | 1.63 | 0.75-3.55 | .219 | 1.16 | 0.61-2.19 | .659 |
| ACEI ≥ 1 y | 1.86 | 0.81-4.27 | .143 | 1.68 | 0.65-4.37 | .285 |
| ARB | 1.71 | 0.92-3.18 | .089 | 0.95 | 0.45-2.02 | .902 |
| ARB ≥ 1 y | 2.11 | 1.11-4.01 | .023 | 1.01 | 0.46-2.20 | .989 |
| Multivariate analysis* | ||||||
| OR | 95%CI | P | OR | 95%CI | P | |
| ACEI/ARB | 1.06 | 0.39-2.83 | .915 | 1.07 | 0.25-4.64 | .927 |
| ACEI/ARB ≥ 1 y | 1.57 | 0.58-4.26 | .369 | 1.03 | 0.23-4.60 | .964 |
| ACEI | 1.15 | 0.40-3.36 | .807 | 1.18 | 0.24-5.83 | .840 |
| ACEI ≥ 1 y | 1.25 | 0.39-4.06 | .708 | 0.98 | 0.17-5.67 | .976 |
| ARB | 0.94 | 0.36-2.47 | .895 | 0.92 | 0.22-3.89 | .912 |
| ARB ≥ 1 y | 1.35 | 0.51-3.56 | .544 | 1.05 | 0.24-4.53 | .945 |
| Propensity score matching | ||||||
| OR | 95%CI | P | OR | 95%CI | P | |
| ACEI/ARB | 0.78 | 0.29-2.08 | .618 | 1.20 | 0.37-3.89 | .764 |
| ACEI/ARB ≥ 1 y | 0.72 | 0.26-2.02 | .528 | 1.93 | 0.59-6.24 | .279 |
| ACEI | 1.26 | 0.38-4.13 | .704 | 1.29 | 0.29-5.77 | .743 |
| ACEI ≥ 1 y | 1.34 | 0.35-5.06 | .669 | 1.17 | 0.20-6.77 | .862 |
| ARB | 0.58 | 0.18-1.87 | .583 | 0.35 | 0.27-3.24 | .913 |
| ARB ≥ 1 y | 0.51 | 0.14-1.86 | .310 | 1.94 | 0.56-6.70 | .295 |
95%CI, 95% confidence interval; ACEI, angiotensin-converting enzyme inhibitors; ARB, angiotensin receptor blockers; OR, odds ratio.
Whole cohort: adjustment of variables with P < .05 in univariate analysis (fever, arterial oxygen saturation < 95%, age, sex, obesity, health care worker, care dependency, hypertension, diabetes, dyslipidemia, peripheral artery disease, heart disease, atrial fibrillation, lung disease, renal impairment, stroke/ transient ischemic attack). Cohort admitted to hospital: adjustment of variables with P < .05 in multivariate analysis (fever, arterial oxygen saturation < 95%, age, sex, obesity, health care worker, care dependency, hypertension, diabetes, dyslipidemia, peripheral artery disease, heart disease, atrial fibrillation, lung disease, renal impairment, stroke/transient ischemic attack, hemoglobin, leukocytes, lymphocytes, creatinine, elevated troponin levels, D-dimer, ferritin, C-reactive protein, interleukin-6) (table 1 of the supplementary data).