Table 5.

Medications used in COVID-19 infection and drug interaction.

COVID Therapy	Interaction	Cardiovascular Related Effects
Chloroquine hydroxychloroquine	Inhibition of lysosomal enzymes in the myocyte	QT prolongation
	CYP2D6 inhibition	↑beta-blocker effect (metoprolol and carvedilol)
Azithromycin	QT prolonging drugs Electrolyte imbalance	QTc prolongation
Lopinavir/ritonavir	Avoid other QT prolonging drugs Avoid electrolyte imbalance	QTc, PR interval prolongation
	CYP3A4 inhibition	↑Ticagrelor level ↓Clopidogrel, Prasugrel level
Ribavirin and lopinavir/ritonavir	Warfarin, Apixaban, Rivaroxaban	Increased bleeding risk with factor Xa inhibitors