Table 3:
Association between factor VIII and risk of clinical outcomes in the Jackson Heart Study
| Model 1 | Model 2 | Model 3 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Outcome | N | Events | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |||
| Stroke | 2990 | 110 | 1.09 | 0.92 | 1.30 | 0.31 | 1.06 | 0.87 | 1.28 | 0.57 | 1.02 | 0.84 | 1.24 | 0.87 |
| Overall CHD | 2899 | 147 | 1.13 | 1.00 | 1.28 | 0.05 | 1.06 | 0.93 | 1.22 | 0.37 | 1.05 | 0.92 | 1.21 | 0.46 |
| Hard CHD | 2905 | 101 | 1.22 | 1.08 | 1.39 | 0.001 | 1.16 | 1.01 | 1.35 | 0.04 | 1.15 | 1.00 | 1.33 | 0.05 |
| Heart Failure | 2755 | 190 | 1.21 | 1.10 | 1.32 | <0.0001 | 1.15 | 1.03 | 1.28 | 0.01 | 1.15 | 1.04 | 1.28 | 0.01 |
| Mortality | 3172 | 559 | 1.22 | 1.14 | 1.30 | <0.0001 | 1.18 | 1.10 | 1.27 | <0.0001 | 1.16 | 1.08 | 1.25 | <0.0001 |
Abbreviations: CHD=coronary heart disease; HR=hazard ratio; CI=confidence interval; CRP=C-reactive protein.
Hazard ratios are reported per standard deviation of factor VIII. Only individuals with complete covariates for all models are included. Model 1: Adjusted for age, sex; Model 2: Model 1 + BMI, blood pressure medications, type 2 diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, current smoking; Model 3: Model 2 + CRP