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. Author manuscript; available in PMC: 2021 Jun 5.
Published in final edited form as: Circ Res. 2020 Mar 20;126(12):1779–1794. doi: 10.1161/CIRCRESAHA.120.316659

Figure 6: Deletion of integrin α9 on myeloid cells improves stroke outcome and enhances the sensorimotor recovery in aged mice.

Figure 6:

A. Schematic of experimental design. B. Left: Representative magnetic resonance imaging from 1 mouse of each group on day 1. White is the infarct area. Right: Corrected mean infarct volumes of each genotype (n=13, 11). C. Neurological outcome (Bederson score) from each genotype as assessed on day 1 (higher score indicates a worse outcome, n=13, 11). D. The survival rate after 60 min transient ischemia. E. Modified neurological severity score (mNSS) at days 1, 3, and 7 based on spontaneous activity, symmetry in the movement of 4 limbs, forepaw outstretching, climbing, body proprioception and responses to vibrissae touch (higher score indicates a better outcome, n=13, 11, 6,10, 4, 7). F. Post-stroke neurological, behavioral recovery as analyzed by cylinder test on day 7, n=4, 7. G. Post-stroke motor function as analyzed by accelerated rotarod on 7, n=4, 7. Data are mean ± SEM (6B) and median ± range (6C, 6E, 6F and 6G). Statistical analysis: unpaired t test (6B), Mann-Whitney test (6C, 6F and 6G) Comparison of survival curves was evaluated by log-rank (Mantel-Cox) test (6D), Kruskal-Wallis test followed by Fisher’s LSD multiple comparisons test (6E).