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. Author manuscript; available in PMC: 2021 Jun 5.
Published in final edited form as: Circ Res. 2020 Mar 20;126(12):1779–1794. doi: 10.1161/CIRCRESAHA.120.316659

Figure 7: Infusion of anti-integrin α9 antibody improves stroke outcome and enhances long-term sensorimotor activity in the comorbid condition of hyperlipidemia.

Figure 7:

A. Schematic of experimental design. B. Left: Representative magnetic resonance imaging from 1 mouse of each group on day 1. White is the infarct area. Right: Corrected mean infarct volumes of each genotype (n=11,12). C. Modified Neurological Severity Score (mNSS) at weeks-1, 2, 3 and 4 based on spontaneous activity, symmetry in the movement of 4 limbs, forepaw outstretching, climbing, body proprioception and responses to vibrissae touch (higher score indicates a better outcome, n=7/group). Post-stroke sensorimotor behavioral recovery at week-1, 2, 3 and 4 as analyzed by D. cylinder test, n=7/group E. accelerated rotarod, n=7/group F. contact time in adhesive tape removal test, n=7/group and G. removal time in adhesive tape removal test, n=7/group. Data are mean ± SEM (7B) and median ± range (7C, 7D, 7E, 7F and 7G). Statistical analysis: unpaired t test (7B), two-way ANOVA followed by Fisher’s LSD multiple comparisons test (7C, 7D, 7E, 7F and 7G).