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. 2020 Apr 17;21(3):182–192. doi: 10.1038/s41435-020-0097-5

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© The Author(s), under exclusive licence to Springer Nature Limited 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — SHR-A3 and SHR-A3(Stim1-B2) rats were maintained for 8 weeks on a stroke-inducing diet (1% NaCl in drinking water) starting at 20 weeks of age. a Gross morphology of the brains from SHR-A3 rats revealed global cerebral edema, evidenced by the filling in of major brain sulci (dashed arrows) in SHR-A3 rats. A hemorrhage is also visible (solid arrow). b Quantification of microbleeds in SHR-A3 and SHR-A3(Stim1-B2) rats. c Representative image of a brain slices showing a hemorrhagic lesions (solid arrow) and microbleeds (dashed arrows) in SHR-A3 rats. Hash (#) indicates P < 0.05 vs SHR-A3 with n = 9 (SHR-A3), n = 10 (SHR-A3(Stim1-B2)).