Fig. 4.
The effect of concomitant steady-state CBD on individual and geometric mean steady-state exposure (Cmax and AUCtau) of a STP, b VPA, and c 4-ene-VPA and d treatment ratios with 90% CIs for STP, VPA, and 4-ene-VPA (PK population). Patient numbers for dn = 9 (STP AUCtau); n = 9 (STP Cmax); n = 10 (VPA AUCtau); n = 10 (VPA Cmax); n = 10 (4-ene-VPA AUCtau); n = 10 (4-ene-VPA Cmax). 4-ene-VPA 2-propyl-4-pentenoic acid, AED antiepileptic drug, AUCtau area under the plasma concentration–time curve over a dosing interval, where tau is the dosing interval, CBD cannabidiol, CI confidence interval, Cmax maximum observed plasma concentration, PK pharmacokinetics, STP stiripentol, VPA valproate