Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 5;3:293. doi: 10.1038/s42003-020-1018-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a PCA plot showing divergence of transcriptional response to lung infection within the ear (9–47-Ear) and blood isolates (4559-Blood). rafR swap (9–47M) rewires pneumococcal transcriptional response only in the ear isolate background but not in the blood isolate. b Differential expression due to the rafR swap in the ear isolate background is spread throughout the pneumococcal genome. c Differential expression due to the rafR swap in the blood isolate background is limited to a genomic island. d–f Functional enrichment showed specific function being differentially expressed, including carbohydrate metabolism (d), ABC transporters (e), and sugar transporters (f). A: comparison of 9–47-Ear to 9–47M; B: 9–47-Ear to 4559-Blood; C: 9–47-Ear to 4559M; D: 9–47M to 4559-Blood; E: 9–47M to 4559M and F: 4559-Blood to 4559M. Asterisk (*) denotes statistically significant functional enrichment for the indicated strain–strain comparison.