Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 5;11:2841. doi: 10.1038/s41467-020-16639-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — Neutralization titers from mouse serum following immunization using WT VLPs-1 (cyan), WT VLPs-2 (blue), Gardasil 9 (brown), Cervarix (green), nona-type chVLP-1 (orange), and nona-type chVLP-2 (magenta). Titers were measured by PBNA covering the nine HPV types included in the vaccines (a–c) and the 11 non-vaccine HPV types (d–f). Eighteen groups of mice were immunized with three dosages (13.5 μg, 1.35 μg, and 0.135 μg) of the six different vaccines at 0, 2, and 4 weeks. Serum samples were collected 2 weeks after the third immunization. N = 10 mice in each group. The neutralization titers were presented as mean ± SD. Statistical significance was assessed by two-way ANOVA: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Non-neutralization samples were assigned a value of half of the limit of detection for visualization (the dotted line). Source data and exact p values are provided as a source data file.