Fig. 4. Effects of B-cell depletion on AQP4-Ig + and MOG-Ig + NMOSD.
a Comparison of relapse rates in AQP4-Ig + (n = 12) and MOG-Ig+ NMOSD (n = 5) who are B-cell-sufficient. b Comparison of relapse rates in AQP4-IgG+ (n = 13) and MOG-IgG+ (n = 7) NMOSD who are B-cell-deficient. P values were determined using two-tailed Mann–Whitney tests. Serum c IL-6 and d MCP-3 levels in B cell-sufficient AQP4-IgG+ patients (n = 13), B-cell-deficient AQP4-IgG+ patients (n = 13), B-cell-sufficient MOG-IgG+ patients (n = 5) and B-cell-deficient MOG-IgG+ patients (n = 7) were compared with healthy controls (n = 18). P values were determined using one-way ANOVA tests with multiple comparisons corrected by the Tukey’s method. Error bars indicate the S.E.M. Source data are provided as a Source Data file.