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. 2020 Jun 5;11:2856. doi: 10.1038/s41467-020-16625-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Correlation between composite IFN scores and serum CXCL11 levels with IL-6 in B cell-sufficient NMOSD patients (n = 18), B-cell-deficient NMOSD patients (n = 20) and healthy volunteers (n = 18). R and p values were determined using two-tailed Pearson correlation coefficient tests. Direct effect of IFN-β on human naive and memory B cells was assessed by stimulating purified human naïve (CD27⁻) and memory B cells (CD27⁺) from healthy donors (n = 4) with CD40L, anti-Ig ± IFN-β. Representative flow cytometric plots and frequency of live b naive CD19⁺ B cells and c memory B cells expressing CD80, CD86, and IL-6 are shown. Statistical significance was determined using two-tailed Student t tests. P values <0.05 were considered significant.