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. 2020 Jun 5;11:2856. doi: 10.1038/s41467-020-16625-7

Fig. 7. IL-6 blockade attenuates IFN-β-treated TH17-EAE.

Fig. 7

TH17-EAE mice, either treated with IFN-β or vehicle, were also treated with either anti-IL-6R or an isotype control every 5 days from days 1–11. a Effect of treatment with anti-IL-6R (n = 10) or isotype (n = 10) control on the clinical scores of vehicle-treated TH17-EAE. Data were pooled from two independent experiments. b Number of CD4+ T cells that express GM-CSF and IL-17 in spinal cords of vehicle-treated mice (day 35). c Effect of anti-IL-6R (n = 8) or isotype (n = 10) treatment on the clinical scores of IFN-β-treated TH17-EAE. Data were pooled from two independent experiments. Vehicle/isotype treated mice were also plotted for reference. d Number of CD4+ T cells that express GM-CSF and IL-17 in the spinal cords of IFN-β-treated EAE mice (day 35). Statistical analysis was performed using Mann–Whitney tests (P < 0.05). Error bars indicate the S.E.M. Results are compiled from two independent experiments.