Table 2.
Study data types.
| Study start visit | Quarterly follow-upsa | Annual visit | Quarterly follow-upsa | Annual visit | Quarterly follow-upsa | Annual visit | Quarterly follow-upsa | Annual visit | |
|---|---|---|---|---|---|---|---|---|---|
| Onsite consent | X | ||||||||
| Pregnancy test | X | X | X | X | X | X | X | X | X |
| Medical history | X | X | X | X | X | X | X | X | X |
| Clinical assessments | |||||||||
| Ankle-brachial index | X | X | X | X | X | ||||
| Audiometry | X | X | X | X | X | ||||
| Cognition | X | X | X | X | X | ||||
| Neuropsychiatric | X | X | X | X | X | ||||
| Physical examination | X | X | X | X | X | ||||
| Physical performance | X | X | X | X | X | ||||
| Pulmonary function testing | X | X | X | X | X | ||||
| Visual performance testing | X | X | X | X | X | ||||
| Vitals | X | X | X | X | X | X | X | X | X |
| Biospecimen collection | |||||||||
| Blood | X | X | X | X | X | X | X | X | X |
| Saliva | X | X | X | X | X | X | X | X | X |
| Stool | X | X | X | X | X | X | X | X | X |
| Swabs (buccal, retroauricular, nares and oral microbiome) | X | X | X | X | X | X | X | X | X |
| Tears | X | X | X | X | X | X | X | X | X |
| Tissue | Throughout | ||||||||
| Urine | X | X | X | X | X | X | X | X | X |
| Imaging | |||||||||
| Coronary calcium scan | X | ||||||||
| Echocardiogram | X | X | |||||||
| Stress echocardiogram | X | X | |||||||
| Electrocardiogram | X | X | |||||||
| Keratometry/corneal topography | X | X | X | ||||||
| Optical coherence tomography (OCT) | X | X | X | ||||||
| Posterioranterior (PA) and lateral chest X-ray | X | ||||||||
| Retinal photography | X | X | X | ||||||
| Sensors | |||||||||
| Study watch | Throughout | ||||||||
| Study hub | Throughout | ||||||||
| Sleep sensor | Throughout | ||||||||
| Mobile sensors | Throughout | ||||||||
| Self-reported data | |||||||||
| Self-reported data | Throughout | ||||||||
| Other | |||||||||
| Health records | Throughout | ||||||||
| Claims data | Throughout |
A broad range of health assessments are conducted in the deeply phenotyped cohort to capture potentially important markers of health and disease.
aFor participants at elevated risk only. Assessments and biospecimen collection may be reduced over time depending on participant availability and compliance.