Table 2.
Laboratory findings of neutrophil to CD4+ lymphocyte ratio in patients with COVID-19.
| Variable (unit, normal range) | Total (n = 95) | ≤ 0.012533 (n = 48) | > 0.012533 (n = 47) | P value |
|---|---|---|---|---|
| Blood cytology | ||||
| Leukocytes (3.5 ~ 9.5 × 109/L), median (IQR) | 5.66 (3.59–8.93) | 3.99 (3.10–5.63) | 9.24 (5.76–10.70) | P < 0.001 |
| Neutrophils (1.8 ~ 6.3 × 109/L), median (IQR) | 3.81 (2.47–7.21) | 2.51 (1.63–3.36) | 8.11 (4.62–9.62) | P < 0.001 |
| Platelets (125 ~ 350 × 109/L), median (IQR) | 189 (134–230) | 186 (156–225) | 203 (120–267) | 0.454 |
| Monocytes (0.1 ~ 0.6 × 109/L), mean ± SD | 0.52 ± 1.01 | 0.38 ± 0.16 | 0.66 ± 1.41 | 0.101 |
| Lymphocytes (1.1 ~ 3.2 × 109/L), median (IQR) | 0.77 (0.52–1.07) | 1.04 (0.77–1.46) | 0.58 (0.32–0.77) | P < 0.001 |
| CD3+ (805 ~ 4459/μL) | 477 (299–781) | 774 (572–1095) | 324 (195–455) | P < 0.001 |
| CD3 + CD4+ (345 ~ 2350/μL) | 290 (153–518) | 513 (304–625) | 180 (109–274) | P < 0.001 |
| CD3 + CD8+ (345 ~ 2350/μL) | 189 (114–330) | 312 (197–423) | 123 (71–179) | P < 0.001 |
| CD4/CD8 ratio (0.96 ~ 2.05) | 1.52 (1.05–2.29) | 1.50 (1.11–2.04) | 1.54 (1.04–2.51) | 0.929 |
| CD19+ (240 ~ 1317/μL) | 118 (49–187) | 149 (74–225) | 81 (31–153) | 0.005 |
| CD16 + CD56+ (210 ~ 1514/μL) | 126 (49–208) | 173 (100–250) | 57 (22–164) | P < 0.001 |
| Blood inflammatory indicators, median (IQR) | ||||
| CRP (0 ~ 10 mg/L) | 21.7 (5.8–76.3) | 11.4 (3.1–35.3) | 69.8 (16.6–119.3) | P < 0.001 |
| ESR (0 ~ 15 mm/h) | 26.5 (10.0–46.7) | 18.5 (8.0–32.0) | 46.5 (31.0–78.5) | P < 0.001 |
| Blood biochemistry | ||||
| ALT (9 ~ 50 U/L), median (IQR) | 24 (18–38) | 22 (16–32) | 25 (20–50) | 0.269 |
| AST (15 ~ 40 U/L), median (IQR) | 27 (18–39) | 27 (18–35) | 29 (19–52) | 0.053 |
| ALB (40 ~ 55 g/L), mean ± SD | 34.9 ± 5.8 | 37.5 ± 4.8 | 32.1 ± 5.5 | P < 0.001 |
| GLB (20 ~ 30 g/L), median (IQR) | 29.2 (26.5–32.0) | 28.5 (26.0–30.6) | 30.8 (27.7–34.9) | P < 0.001 |
| GGT (8 ~ 57 U/L), median (IQR) | 29 (18–49) | 23 (16–38) | 36.5 (23–67) | 0.007 |
| ALP (30 ~ 120 U/L), mean ± SD | 75 ± 26 | 72 ± 24 | 78 ± 27 | 0.361 |
| Creatinine kinase (<171 U/L), mean ± SD | 62 ± 18 | 56 ± 14 | 68 ± 21 | 0.006 |
| LDH (125–243 U/L), median (IQR) | 209 (176–289) | 192 (154–252) | 275 (206–450) | 0.001 |
| CKMB (0 ~ 6.6 ng/mL), median (IQR) | 70 (43–133) | 70 (47–109) | 84 (36–207) | 0.387 |
Abbreviation: COVID-19, coronavirus disease 2019; No., number; SD, standard deviation; IQR, interquartile range; AST, aspartate aminotransferase; ALB, albumin; GLB, globulin; GGT, glutamyltranspetidase; ALP, alkaline phosphatase; LDH, lactate dehydrogenase; CKMB, MB isoenzyme of creatine kinase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; ALT, alanine aminotransferase.