Table 4.
Information on hub genes.
| Gene symbol | Gene name | Degree | Closeness |
|---|---|---|---|
| IL-6 | Interleukin-6 | 50 | 64.33333 |
| CASP3 | Caspase-3 | 48 | 63.33333 |
| MAPK8 | Mitogen-activated protein kinase 8 | 47 | 62.5 |
| VEGF-A | Vascular endothelial growth factor A | 47 | 62.5 |
| EGFR | Epidermal growth factor receptor | 46 | 62.16667 |
| MYC | Myc protooncogene protein | 45 | 61.5 |
| ESR1 | Estrogen receptor | 44 | 61 |
| CCND1 | G1/S-specific cyclin-D1 | 42 | 60 |
| FOS | Protooncogene c-Fos | 38 | 58.5 |
| ERBB2 | Receptor tyrosine-protein kinase erbB-2 | 36 | 56.83333 |
| AR | Androgen receptor | 34 | 56 |
| RELA | Transcription factor p65 | 32 | 55.5 |
| PPARG | Peroxisome proliferator activated receptor gamma | 32 | 55 |
| NOS3 | Nitric oxide synthase, endothelial | 29 | 53.83333 |
| PGR | Progesterone receptor | 28 | 53 |
| CASP8 | Caspase-8 | 27 | 52 |
| CAV1 | Caveolin-1 | 26 | 51.5 |
| AHR | Aryl hydrocarbon receptor | 25 | 51.16667 |
| ICAM1 | Intercellular adhesion molecule 1 | 24 | 51 |
| HIF-1α | Hypoxia-inducible factor 1-alpha | 24 | 51 |
| CASP9 | Caspase-9 | 24 | 50.66667 |
| RB1 | Retinoblastoma-associated protein | 22 | 49.66667 |
| CYP3A4 | Cytochrome P450 3A4 | 21 | 49.5 |
| NFE2L2 | Nuclear factor erythroid 2-related factor 2 | 21 | 49.33333 |
| NFKBIA | NF-kappa-B inhibitor alpha | 20 | 48.66667 |
| NQO1 | NAD(P)H dehydrogenase [quinone] 1 | 20 | 48.33333 |