Table 5.
Antifungal Treatment for 4 Patient Categories of Infection Over Time
| Category of Disease | Initial,a No. (%) | 3 Months,a No. (%) | 6 Months,a No. (%) | 12 Months,a No. (%) |
|---|---|---|---|---|
| Meningitis/stroke (No. of patients) | (82) | (66) | (62) | (38) |
| Voriconazole | 81 (99) | 56 (85) | 42 (68) | 2 (5) |
| Amphotericin B | 32 (39) | 4 (6) | 2 (3) | — |
| Itraconazole | 3 (4) | 5 (8) | 5 (8) | — |
| Posaconazole | 2 (2) | 2 (3) | 1 (2) | 1 (3) |
| Spinal/paraspinal (No. of patients) | (223) | (210) | (206) | (148) |
| Voriconazole | 192 (86) | 199 (95) | 171 (83) | 25 (17) |
| Amphotericin B | 35 (16) | 9 (4) | 12 (6) | 3 (2) |
| Itraconazole | 4 (2) | 20 (10) | 65 (32) | 37 (25) |
| Posaconazole | — | — | 2 (1) | 7 (5) |
| Meningitis/stroke and spinal/paraspinal (No. of patients) | (123) | (114) | (107) | (89) b |
| Voriconazole | 113 (92) | 105 (92) | 96 (90) | 13 (15) |
| Amphotericin B | 42 (34) | 41 (36) | 15 (14) | 6 (7) |
| Itraconazole | — | 6 (5) | 23 (21) | 15 (17) |
| Posaconazole | 8 (7) | 4 (4) | 3 (3) | 2 (2) |
| Osteoarticular infection (No. of patients) | (12) | (12) | (11) | (8) |
| Voriconazole | 12 (100) | 7 (64) | 7 (58) | — |
| Itraconazole | — | 5 (45) | 7 (58) | 4 (50) |
| Posaconazole | — | — | 1 (8) | — |
aNumbers listed are greater than the total number of patients in each category because many patients received several antifungal agents either in combination or sequentially.
bOne patient received isavuconazole.