Figure 3. Simulated Plasma Exposures for Remdesivir in Children and Adults.

Simulated plasma exposures for remdesivir (area under the plasma concentration time curve from time 0 to infinity) in children and adults for the proposed dosing algorithm. Exposures representative of loading dose administration. Age classifications are based on postnatal age and are defined as follows: neonate (0 to <30 days), young infant (1 to <6 months), infant (6 to <24 months), young child (2 to <6 years), child (6 to <12 years), adolescent (12-18 years), and adult (20-50 years). Horizontal lines of the box correspond to the first quartile, median, and third quartiles. Upper whiskers extend from the third quartile to the largest observation to a maximum length of 1.5 times the interquartile range (ie, third quartile to first quartile). Lower whiskers extend from the first quartile to the lowest observation to a maximum length of 1.5 times the interquartile range (ie, third quartile to first quartile).