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. 2020 Jun 5;11:45. doi: 10.1186/s13229-020-00354-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Differential expression analysis of RNA-seq data from mouse brain regions. a Expression of Mbd5 mRNA as normalized counts in three brain regions: cerebellum (Cb), striatum (St), and cortex (Cx). b Volcano plots of differential expression analysis per region. c Gene overlaps in differentially expressed genes in mouse brain regions. The color indicates the significance (−log₁₀(p)) of Fisher’s enrichment test, and the number shows the number of overlapping DEGs at nominal significance. Only the genes that were present in all tests were considered as background for enrichment tests and for overlap analyses. d Meta-analysis of p values from differential gene expression comparisons in each brain region using Fisher’s method. The color in the heatmap shows whether the gene was significantly up- or downregulated in a corresponding brain region. “Direction” indicates whether the gene was analyzed in a group of upregulated genes or downregulated genes. “metaP.adj” shows the p value of meta-analysis using Fisher’s method. e Enrichments of differentially expressed genes at FDR and at nominal significance in gene sets previously associated with brain development and developmental disorders. The description of gene lists is provided in Supplementary Tables 5 & 6.