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. 2020 Jun 5;11:45. doi: 10.1186/s13229-020-00354-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Co-expression network analysis in mouse brain regions. a Enrichments of co-expression modules in each brain region for differentially expressed genes. Only modules with significant enrichments are shown. The color of the heatmap shows the −log10(p) of Fisher’s enrichment test, and the number shows number of genes that overlap. The number next to the module name in the columns shows total number of expressed genes in that module. b Eigenvalues of modules with significant differences in values between two genotypes. The value in each plot title shows corresponding p value of t test between eigenvalues of two genotypes. c Enrichments of genes from striatum and cortex co-expression modules. Only modules with enrichment for nDEGs and a corresponding overlapping module from the other brain region are shown. The color of the heatmap shows the −log10(p) of Fisher’s enrichment test, and the number shows number of genes that overlap. The number next to the module name in the columns shows total number of expressed genes in that module