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Changes in the six biomarkers among different groups of patients at different times by ELISA. Concentration of CA1 (a), MMP9 (b), QPCT (c), HCAR2 (d), UGCG (e), and LDHB (f) in serum samples of the healed (n = 18), nonunion (n = 9), healed+DR (n = 21), and nonunion+DR (n = 7) groups at time points 0, 3, 6, 9, and 12 months. Data are represent as the means ± SEM. **p < 0.01 vs. healed group, #p < 0.05 vs. nonunion group
