Table 5.

Association between baseline factors and changes in T1/ECV

	T1 SAX Mid Gradient (ms per Year)			T1 SAX Mid ECV Gradient (pp per Year)
	N	Mean ± SD	p-Value	N	Mean ± SD	p-Value
Age at First Scan*	26	−0.137*	0.505*	24	0.169	0.430
Ethnicity			0.278			0.360
White British	18	26.3 ± 25.2		17	1.8 ± 2.5
Other	8	12.7 ± 35.9		7	0.7 ± 2.6
Gender			0.112			0.864
Male	17	15.5 ± 29.4		15	1.4 ± 2.5
Female	9	34.5 ± 24.8		9	1.6 ± 2.8
ACE/ARB			0.969			0.771
No	6	21.7 ± 56.6		5	1.8 ± 2.9
Yes	20	22.2 ± 16.0		19	1.4 ± 2.5
Statins/Fibrates			0.103			0.121
No	14	30.7 ± 22.5		14	2.1 ± 2.8
Yes	12	12.1 ± 33.1		10	0.5 ± 1.7
Hypertension			0.930			0.117
No	11	21.5 ± 35.6		10	0.5 ± 2.4
Yes	15	22.5 ± 24.2		14	2.1 ± 2.4
Hyperlipidaemia			0.040			0.989
No	11	35.5 ± 21.8		11	1.5 ± 2.2
Yes	15	12.3 ± 30.1		13	1.5 ± 2.8
Infantile cardiomyopathy			0.710			0.904
No	16	20.4 ± 33.0		15	1.5 ± 2.9
Yes	10	24.9 ± 22.0		9	1.4 ± 1.9
Diabetes			0.764			0.132
No	9	19.7 ± 39.3		9	0.5 ± 2.5
Yes	17	23.4 ± 23.0		15	2.1 ± 2.4
Insulin resistance (not diabetes)			0.752			0.870
No	20	21.1 ± 30.2		18	1.5 ± 2.6
Yes	6	25.5 ± 26.3		6	1.3 ± 2.4
CKD			0.889			0.630
No	12	23.0 ± 33.3		12	1.2 ± 2.0
Yes	14	21.4 ± 25.8		12	1.7 ± 3.0
Presence of CAD**			0.622			0.121
No	20	23.5 ± 27.5		20	1.0 ± 2.0
Yes	3	32.7 ± 44.7		3	3.4 ± 4.7

Gradients were calculated on a per-patient basis, as described in the methods, with the resulting values reported as mean ± SD, and compared between groups using independent samples t-tests, unless stated otherwise. Only those patients with at least two valid scans for the stated marker were included in the analysis

*Reported as a Spearman’s rho correlation coefficient and p-value. **Excludes N = 3 patients with unknown CAD status. Note that ECV was measured as a percentage, hence gradients are reported in percentage points (pp) per year. Bold p-values are significant at p < 0.05