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. 2020 Jun 5;11:218. doi: 10.1186/s13287-020-01736-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Serum HMGB1, MFI of HMGB1 on monocytes, and HMGB1 expression in liver grafts. A Serum HMGB1 level. The serum HMGB1 level in the HBP group was lower than that in the SCS, NMP, and BP groups (P < 0.05). B MFI of HMGB1 expression on CD43^low monocytes (blue) and CD43^high monocytes (yellow). C1 MFI of HMGB1 on CD43^low monocytes. C2 MFI of HMGB1 on CD43^high monocytes. C3 The MFI of HMGB1 on all monocytes in the HBP group decreased slowly after an increase on day 1, stabilized to near-normal levels on day 14, and was lower than that in the BP group (P < 0.05). The MFI of HMGB1 on all monocytes in the SCS group was significantly higher than those in the other groups at each time point (P < 0.05). D Correlation analysis. A strong positive correlation was observed between serum HMGB1 levels and the MFI of HMGB1 on all monocytes after OLT (r = 0.7931, P < 0.0001). E The protein expression of HMGB1 in monocytes and liver tissues. (^aP < 0.05 vs. SCS group; ^bP < 0.05 vs. NMP group; ^cP < 0.05 vs. HBP group)