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. 2020 Jun 5;15:143. doi: 10.1186/s13014-020-01565-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Examples of patients with desmoid tumors: A 27-year-old patient with a progressive, gigantic, FAP-associated mesenteric desmoid tumor, treatment was performed with photon-IMRT up to 50.4 Gy in 28 fractions, B: The patient developed a new symptomatic desmoid tumor of the abdominal wall 7 years after the primary treatment and was treated with protons 56 Gy (RBE) in 28 fractions. The mesenteric desmoid regressed in size, and stabilized with a cystic appearance on CT and MRI (not shown). C: Thirty-two-year-old patient who was pregnant at diagnosis of a gigantic cervico-thoracic desmoid tumor. The patient was treated beginning in the 28th week of pregnancy with protons, however the tumor progressed rapidly and the treatment was discontinued at 30 Gy (RBE). Caesarean section was performed and treatment with methotrexate and vinorelbine initiated. The tumor regress significantly after that