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. 2020 Jun 5;13:64. doi: 10.1186/s13048-020-00664-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Circ_0078607 directly bound to miR-518a-5p in ovarian cancer cells. a Relative expression level of miR-518a-5p and miR-527 were detected by qRT-PCR in 20 ovarian cancer tissues and paired adjacent normal tissues. b Bivariate correlation analysis of the relationship between circ_0078607 and miR-518a-5p expression level. c The seed sequences of circ_0078607WT/Mut and miR-518a-5p. d Dual-luciferase reporter assays were performed to detect the correlation between miR-518a-5p and circ_0078607. e MiR-518a-5p promoted the proliferation of SKOV3 and A2780 cells. f MiR-518a-5p mimic functionally restored circ_0078607 overexpression-suppressed ovarian cancer cells proliferation. Error bars represent mean ± standard deviation (SD). *p < 0.05, **p < 0.01, ***p < 0.001