Fig. 4.

Fused mitochondria potentiate ERK and Akt signaling in response to different stimuli. We quantified activation of Akt and ERK in SUM159 and MDA-MB-231 cells, respectively, by imaging KTRs. Graphs show earth mover’s distance (EMD) and area-under-the-curve (AUC) for 0, 5, 20, and 60 min after addition of stimulus (10% serum (a–d) or EGF (50 ng/mL, e–h)) relative to baseline signaling before stimulus (0 min) (n ≥ 188 cells per group)