Table 3.

Lithium and Neutrophils

Physiological effects	Enhances production of endogenous G-CSF, directly stimulating differentiation of stem cells and protecting neutrophils from the toxicity of some drugs, although to a far smaller extent than G-CSF.
Haematological usage	Reports of use to treat idiopathic neutropenia [71]
Lithium and clozapine rechallenge	Reviews by Manu (2012) [72] and Boazak (2019) [73] show high rates of success.
Adverse effects in clozapine rechallenge	Isolated case reports of failure / fatality [74] and of neurotoxicity [75]
Use, dose, side effects	Familiar to psychiatrists
Institutional / systemic factors	Systemic difficulties not likley