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. 2020 Jun 5;22:130. doi: 10.1186/s13075-020-02186-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — NK and B cells enhance the type III IFN production in pDCs stimulated with RNA-IC. a, b Relative signal intensity (log2fold change) of mRNA expression in RNA-IC-stimulated, vs mock-stimulated, cells from two healthy blood donors (a and b) after 6 h. Green indicates relative downregulation, black neutral, and red relative upregulation of gene expression. Protein levels of c IFN-λ2 and d IFN-λ1/3 in supernatants after 20-h stimulation. Boxplots show medians with interquartile range (seven donors, three independent experiments). Friedman’s test. *p < 0.05, **p < 0.01, ***p < 0.001