Table 2.
FRAX variables for men and women at baseline and according to frailty status at 15-year follow-up. Values reported as means ±SD, median (IQR), or n (%)
| ALL | Frail | Pre-frail | Robust | p-value | |
|---|---|---|---|---|---|
| Women | N = 302 | N = 46 | N = 168 | N = 88 | |
| Age (yr) | 53 (48–73) | 62 (53–67) | 53 (47–60) | 51 (47–56) | ≤ 0.001 |
| Weight (kg) | 70.8 ± 13.1 | 71.7 ± 13.3 | 71.2 ± 13.2 | 69.6 ± 12.9 | 0.583 |
| Height (cm) | 161.3 ± 6.0 | 159.3 ± 5.2 | 161.3 ± 6.0 | 162.4 ± 6.1 | 0.018 |
| Prior Fracture | 31 (10.3) | 11 (24.0) | 13 (7.7) | 7 (8.0) | 0.004 |
| Parental hip fracture | 18 (6.0) | 4 (8.7) | 10 (6.0) | 4 (4.5) | 0.629 |
| Smoking | 33 (10.9) | 3 (6.5) | 22 (13.1) | 8 (9.1) | 0.362 |
| Glucocorticoids | 2 (0.6) | 1 (2.2) | 1 (0.6) | 0 (0) | a |
| Rheumatoid Arthritis | 24 (7.9) | 8 (17.4) | 14 (8.3) | 2 (2.3) | 0.009 |
| Secondary Osteoporosis | 36 (11.9) | 4 (8.7) | 25 (14.9) | 7 (8.0) | 0.204 |
| Alcohol | 2 (0.7) | 0 (0) | 0 (0) | 2 (2.3) | a |
| BMDb (g/cm2) | 0.928 ± 0.146 | 0.876 ± 0.150 | 0.933 ± 0.153 | 0.946 ± 0.124 | 0.025 |
| Men | N = 302 | N = 46 | N = 158 | N = 98 | |
| Age (years) | 57 (52–65) | 68 (60–76) | 57 (66–52) | 54 (51–59) | ≤ 0.001 |
| Weight (kg) | 83.7 ± 12.7 | 87.3 ± 12.9 | 83.0 ± 13.0 | 83.3 ± 11.9 | 0.108 |
| Height (cm) | 174.5 ± 6.4 | 173.7 ± 7.2 | 174.4 ± 6.1 | 175.0 ± 6.4 | 0.496 |
| Prior Fracture | 49 (16.2) | 6 (13.0) | 29 (18.4) | 14 (14.3) | 0.565 |
| Parental hip fracture | 23 (7.6) | 3 (6.5) | 15 (9.5) | 5 (5.1) | 0.417 |
| Smoking | 31 (10.3) | 3 (6.5) | 17 (5.6) | 11 (11.2) | 0.657 |
| Glucocorticoids | 1 (0.3) | 0 (0) | 1 (0.6) | 0 (0) | a |
| Rheumatoid Arthritis | 7 (2.3) | 1 (2.2) | 6 (3.8) | 0 (0) | 0.145 |
| Secondary Osteoporosis | 4 (1.3) | 0 (0) | 4 (14.9) | 0 (0) | a |
| Alcohol | 82 (27.2) | 12 (26.1) | 44 (27.8) | 26 (26.5) | 0.959 |
| BMD (g/cm2) | 0.982 ± 0.127 | 1.016 ± 0.150 | 0.962 ± 0.116 | 1.000 ± 0.127 | 0.009 |
aToo few to conduct statistical analysis
b Bone mineral density (BMD)