Table 3.
Determination of Fracture Risk Assessment (FRAX) score cut-off points for screening for frailty using Area under the Receiver Operating Characteristic (AUROC) curves using sensitivity and specificity measures
| FRAX scores | Area under the ROC curve (95% CI) | Cut point (Decile) | % Cut point for fracture risk a | Sensitivity | Specificity | Predictive Value (%) | Positive Likelihood ratio (LR+) | Negative Likelihood ratio (LR-) |
|---|---|---|---|---|---|---|---|---|
| Women | ||||||||
| MOFbwith BMDc | 0.72 (0.63–0.80) | 5 | 1.50 (1.06,1.94) | 80.0% | 45.7% | 50.8 | 1.47 | 0.44 |
| MOF without BMD | 0.71 (0.62–0.79) | 5 | 1.60 (1.21,1.99) | 82.2% | 45.0% | 50.5 | 1.50 | 0.40 |
| Hip with BMD | 0.69 (0.60–0.78) | 5 | 0.10 (0.00,0.38) | 84.4% | 30.2% | 38.3 | 1.21 | 0.51 |
| Hip without BMD | 0.68 (0.60–0.77) | 5 | 0.20 (0.02,0.38) | 75.6% | 49.2% | 53.1 | 1.49 | 0.50 |
| Men | ||||||||
| Hip without BMD | 0.76 (0.68–0.82) | 5 | 0.30 (0.12,1.94) | 89.6% | 45.7% | 52.6 | 1.64 | 0.23 |
| MOF without BMD | 0.73 (0.66–0.80) | 5 | 1.65 (1.36,1.94) | 87.5% | 47.7% | 54.0 | 1.67 | 0.26 |
| MOF with BMD | 0.68 (0.60–0.76) | 5 | 1.70 (1.45,1.95) | 79.2% | 46.5% | 51.6 | 1.48 | 0.45 |
| Hip with BMD | 0.67 (0.59–0.75) | 5 | 0.20 (0.05,0.35) | 81.3% | 44.1% | 50.0 | 1.45 | 0.42 |
aReported as median (95% CI) fracture risk percentage
bMOF Major Osteoporotic fractures
cBMD Bone mineral density