Table 1.
The differential KEGG pathways (P < 0.05) between broiler and native bird
| Level 1/level 21 | Pathway | Upregulation2 | Downregulation2 |
|---|---|---|---|
| M-Global and overview maps | Carbon metabolism | Alpha- d -Glucose | |
| M-Metabolism of cofactors and vitamins | Biotin metabolism | HLCS | |
| M-Carbohydrate metabolism | Glycolysis/gluconeogenesis | GCK, ENO | |
| M-Biosynthesis of other secondary metabolites | Neomycin, kanamycin, and gentamicin biosynthesis | HLCS | |
| H-Endocrine and metabolic diseases | Type II diabetes mellitus | IRS1, KCNJ11 | GLUT4, GK |
| O-Endocrine system | Insulin signaling pathway | GLUT4, GK, PHK | |
| O-Endocrine system | Insulin secretion | EPAC, GCK | |
| O-Immune system | Leukocyte transendothelial migration | ERM | EPAC, CTNNA |
1H, human disease; M, metabolism; O, organismal systems.
2Means candidate genes up/downregulated in broilers compared to native chickens.