Table 2.
The differential KEGG pathways (P < 0.05) between broilers and layers
| Level 1/level 21 | Pathway | Upregulation2 | Downregulation2 |
|---|---|---|---|
| M-Lipid metabolism | Ether lipid metabolism | ENPP2 | PLD_2 |
| M-Energy metabolism | Nitrogen metabolism | CA | CA |
| O-Digestive system | Protein digestion and absorption | Pept, KCN | COL1A, CD10 |
| O-Digestive system | Mineral absorption | MT, TF, HEPH | CIC-2 |
| O-Immune system | Leukocyte transendothelial migration | ACTB_G1, P130cas, CAMs, NCF1 | EPAC |
| O-Immune system | Chemokine signaling pathway | GRO, CAS, P47PHOX, CD182, GNB1 | |
| O-Immune system | Platelet activation | ACTB_G1, PAR1 | MLCK |
| O-Immune system | Cytosolic DNA-sensing pathway | CCL4, CCL5 | RPC1 |
| O-Endocrine system | Relaxin signaling pathway | GNB1 | |
| H-Endocrine and metabolic diseases | AGEs RAGE signaling pathway in diabetic complications | COL, FN | COL, FN |
| E-Signaling molecules and interaction | CAMs | MHC, SN, CD6, NCAM, NGL2, CLDN, MPZ | |
| E-Signaling molecules and interaction | ECM-receptor interaction | AGRN, CHAD, CD104 | TN |
| C-Cellular community—eukaryotes | Tight junction | CGN, ACTB_G1, MPP4, CFTR, CACNA1D, MYH |
1C, cellular process; E, environmental information processing; H, human disease; M, metabolism; O, organismal systems.
2Means candidate genes up/downregulated in broilers compared with layers chickens.