Table 2:
De novo CNV frequencies
| Delivery | Dose | # pups | De novo CNVs | Maternally derived1 | Paternally derived1 | Unknown parental origin | Maximum frequency of paternally derived CNVs2 | p-value3 |
|---|---|---|---|---|---|---|---|---|
| Gavage | 0 mg/kg | 22 | 1 | 1 | 0 | 0 | 0/22 (0%) | - |
| Gavage | 60 mg/kg | 58 | 4 | 3 | 0 | 1 | 1/58 (1.72%) | 1.00 |
| Pump | 0 mg/kg/hr | 21 | 0 | 0 | 0 | 0 | 0/21 (0%) | - |
| Pump | 17.4 mg/kg/hr | 42 | 4 | 1 | 1 | 2 | 3/42 (7.1%) | 0.299 |
| Combined | NT | 43 | 1 | 1 | 0 | 0 | 0/43 (0%) | - |
| Combined | Treated | 100 | 8 | 4 | 1 | 3 | 4/100 (4.00%) | 0.316 |
1
Parental origin determined by SNP analysis.
2
Assumes all CNVs with unknown parental origin are paternal.
3
Fisher’s exact test, treated compared to untreated in each delivery group.