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AICAr, hypoxanthine, and xanthine are increased in CSF of patients with LND. (A–D) Hypoxanthine, xanthine, AICAr, and uric acid concentration in CSF samples of control individuals (n = 17) and patients with LND (n = 17) were determined by HPLC. The results are expressed as micromoles per liter as the mean ± SEM ****P < 0.0001. Mann–Whitney test.
