Table 2. Associations of SERPINA5 and TIMP1 expression with clinical variables in CGGA dataset.
| Overall survival | Univariate | Multivariate | ||
|---|---|---|---|---|
| P-value | HR [95% CI] | P-value | HR [95% CI] | |
| Age | 0.066 | 1.037[0.998–1.078] | ns | – |
| Gender: male vs female | 0.474 | 1.342[0.599–3.006] | ns | – |
| Histology, Astrocytoma | 0.104 | 2.024[0.866–4.731] | ns | – |
| Oligoastrocytoma/Oligodendroglioma | ns | – | ||
| KPS: ≥70 vs <70 | 0.001 | 0.127[0.037–0.434] | ns | – |
| IDH1: mut vs wild type | 0.305 | 0.656[0.293–1.467] | ns | – |
| Tumor grade: Grade ?vs Grade? | 0.000001 | 8.883[3.670–21.501] | 0.000257 | 5.551[2.214–13.915] |
| SERPINA5 expression: high vs low | 0.103 | 0.473[0.192–1.164] | ns | – |
| TIMP1 expression: high vs low | 0.000478 | 8.656[2.578–29.060] | 0.014 | 4.825[1.370–17.000] |
Notes.
Bold font indicates statistical significance.
- KPS
- karnofsky performance score
- IDH1
- isocitrate dehydrogenase 1
- SERPINA5
- Serpin family A member 5
- TIMP1
- TIMP Metallopeptidase Inhibitor 1
- HR
- Hazard ratio
- CI
- confidence intervals