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. 2020 Jun 3;8:e9281. doi: 10.7717/peerj.9281

Figure 1. GPT combined with PTX inhibit MB231-PR cell viability and induce cell apoptosis.

Figure 1

(A) Single treatment of GPT on MB231-PR cell viability. Cells were treated with different concentration of GPT for 4 days. (B) Combination treatment of GPT and PTX on MB231-PR cell viability. Cells were treated with DMOS, 75 nM PTX, 10 μM GPT, 75 nM PTX + 2.5 μM GPT, 75 nM PTX + 5 μM GPT, 75 nM PTX + 10 μM GPT, respectively. (C) Combination treatment of GPT and PTX on MB231-PT cell viability. Cells were treated with DMSO, 1 nM PTX, 10 μM GPT, and different combination, respectively. (D) Representative images of colony formation assay. MB321-PR cells were treated for 12 days with DMSO, 75 nM PTX, 10 μM GPT and combination, respectively. (E) Flow cytometry detection of cell cycle after treatment for 48 h and 72 h. *P < 0.05, ***P < 0.001, ****P < 0.0001. P-values were calculated with t test.