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Gdf15−/− mice are protected against CLP and have decreased CFUs in the peritoneum. (A) Survival to CLP comparing WT (n = 20) and Gdf15−/− (n = 19) animals. (B) Rectal temperature in WT (n = 28) and Gdf15−/− (n = 26) animals 8 and 24 h after CLP. (C) CFUs cultured from peripheral blood of WT (n = 6) and Gdf15−/− (n = 6) animals at 8 h after CLP. (D) CFUs cultured from peritoneal lavage of WT (n = 5) and Gdf15−/− (n = 4) mice at 8 h after CLP.
